- Stimulate Growth Hormone Release Hormone
- Release of GABA (for relaxation and recovery)
- Naturally raises Testosterone production due to up-regulation of STAR.
- Improve Dopamine Levels
- Improve Sexual Function
N-M-DAA In the brain, D-Aspartate gets converted into a very prominent signaling metabolite called NMDA (N-methyl-D-Aspartate). When NMDA reaches the anterior pituitary and hypothalamus, it induces a secretion of Growth Hormone Releasing Hormone (GHRH), Prolactin Releasing Factors (PRFs), and Gonadotropin Releasing Hormone (GnRH). These hormones will then induce the production and secretion of Growth Hormone (GH), Prolactin, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH)… essentially bathing your cells in a wonderful cascade of anabolic hormones.
It also seems to induce the release of both Melatonin-Stimulating Factor and GABA (Gamma Amino Butyric Acid – a relaxing neurotransmitter) in the hypothalamus, which suggests that D-Aspartic acid, would be better taken in the evening. So if we follow the hormonal cascade, LH and FSH travel down to the reproductive organs, and this is where the second tier of D-AA starts in men; the testes.
D-AA acts on the testes on multiple levels. Primarily, D-AA in it’s free form (while circulating in the testes) can up-regulate mRNA synthesis of a protein called STAR (Steroidogenic Acute Regulatory protein). This protein modulates testosterone synthesis in the testes, and increasing its activity raises the limit of testosterone synthesis. The wave of LH from the brain will start testosterone synthesis in the leydig cells of the testes, but at an accelerated capacity due to the up-regulation of STAR.
Dehydroepiandrosterone also known as androstenolone or prasterone (INN), as well as 3β-hydroxyandrost-5-en-17-one or 5-androsten-3β-ol-17-one, is an important endogenous steroid hormone. It is the most abundant circulating steroid in humans, in whom it is produced in the adrenal glands, the gonads, and the brain, where it functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids. However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid.
Chlorophytum Borivilianum has been proposed to increase growth hormone (GH) release and be a testostrone up-regulator. A test of fifteen men ingested the dietary supplement on two different days, separated by one week. Blood was collected from subjects before ingestion of the supplement and at 20, 40, 60, 80, 100, and 120 minutes post ingestion. GH was analyzed in serum samples using an ELISA method. Values for GH for each subject, at each collection time, were averaged over both test days and used in the main analysis.
Results: Serum GH increased over time, with higher values at 60 minutes (1.56 ± 0.65 ng • mL-1; P = 0.04; +767%), 80 minutes (1.76 ± 0.69 ng • mL-1; P = 0.02; +878%), and 100 minutes (1.48 ± 0.62 ng • mL-1; P = 0.05; +722%) compared to pre ingestion (0.18 ± 0.04 ng • mL-1). A great deal of subject variability existed in the area under the curve (AUC) for GH, with pooled values ranging from 0.49 to 61.2 ng • mL-1 • 2 hr-1. Conclusion: Acute ingestion of an investigational dietary supplement containing the active ingredients Chlorophytum borivilianum and results in an increase in circulating GH in exercise-trained men.
Icariin is a flavonol, a type of flavonoid. It is the prenyl acetylation of kaempferide 3,7-O-diglucoside. The compound is derived from several species of plants in the genus Epimedium,which are commonly known as Horny Goat Weed or Yin Yang Huo. Extracts from these plants are reputed to produce aphrodisiac effects, and are commonly used in Chinese herbal medicine to enhance erectile function, as well as for several other indications.
It is thought that icariin is likely to be the primary active component of Epimedium extracts, as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence and improve sexual function. In particular, icariin has been demonstrated to act as a PDE5 inhibitor and to enhance the production of bioactive nitric oxide, as well as mimicking the effects of testosterone. It also shows antioxidant antidepressant and neuroprotective effects in animal studies, as well as stimulating osteoblast activity in bone tissue which has been linked to a possible therapeutic role in the treatment of osteoporosis.
Mucuna pruriens have been used for treating many dysfunctions in Tibb-e-Unani (Unani Medicine), the traditional system of medicine of Indo-Pakistan Subcontinent. It is also used in Ayurvedic medicine.
The plant and its extracts have been long used in tribal communities as a toxin antagonist for various snakebites. Research on its effects against Naja spp. (cobra), Echis (Saw scaled viper), Calloselasma (Malayan Pit viper) and Bangarus (Krait) have shown it has potential use in the prophylactic treatment of snakebites.
Dried leaves of M. pruriens are sometimes smoked.
- pruriens has been shown to improve dopamine levels in rats. The herb contains L-DOPA, a precursor to the neurotransmitter dopamine. The L-DOPA content increases when extracts are prepared. Because of the L-DOPA content, formulations of the seed powder have been studied for the management and treatment of Parkinson’s disease.