INNER-GETIC - Serving Size: 1 scoop (12g)
Container: 30 servings
Protect that hard earned muscle and get rehydrated with an added energy kick!! A 10:1:1 blend you know you're getting the highest quality!
10:1:1(L-Leucine, L-Isoleucine, L-Valine)
Glutamine is the most abundant amino acid (building block of protein) in the body. The body can make enough glutamine for its regular needs, but during times of extreme stress (the kind you would experience after very heavy exercise or an injury), your body may need more glutamine than it can make. Most glutamine is stored in muscles followed by the lungs, where much of the glutamine is made.
Glutamine is important for removing excess ammonia (a common waste product in the body). It also helps your immune system function and may be needed for normal brain function and digestion.
It has been shown that in order for protein balance to become positive post workout, dietary protein, specifically the amino acid leucine, must be consumed and protein balance will remain negative until it is consumed.
Leucine is one of the three branched chain amino acids (BCAAs) and is unique in its ability to stimulate skeletal muscle protein synthesis. In fact, leucine has about a 10 fold greater impact on protein synthesis than any other amino acid!
HICA is claimed to be an anti-catabolic and anabolic agent similar to HMB. The limited evidence that exists right now (literally one study in athletes and a mention of a pilot study conducted by the same researchers) suggests that there is benefit, but beyond needing replication this study is also confounded.
L-Taurine is an amino acid that supports neurological development and helps regulate the level of water and minerals in the blood. Taurine is also thought to have antioxidant properties. L-Taurine is found naturally in meat, fish and breast milk, and it's commonly available as a dietary supplement. Some studies suggest that taurine supplementation may improve athletic performance.
Also known as vitamin C, is necessary for wound healing. It is needed for many functions in the body, including helping the body use carbohydrates, fats, and protein. Vitamin C also strengthens blood vessel walls.
Vitamin B3 (NIACIN), also called nicotinic acid. It occurs naturally in plants and animals, and is also added to many foods as a vitamin supplement. It is also present in many multiple vitamins and nutritional supplements. Niacin is used to treat and prevent a lack of natural niacin in the body, and to lower cholesterol and triglycerides (types of fat) in the blood. It is also used to lower the risk of heart attack in people with high cholesterol who have already had a heart attack. It is sometimes used to treat coronary artery disease (also called atherosclerosis).
VITAMIN B6 refers to a group of chemically very similar compounds which can be interconverted in biological systems. Vitamin B6 is part of the vitamin B complex group, and its active form, Pyridoxal 5'-phosphate (PLP) serves as a cofactor in many enzyme reactions in amino acid, glucose, and lipid metabolism.
Vitamin B12 is required for the proper function and development of the brain, nerves, blood cells, and many other parts of the body.
Surely you are well aware that caffeine’s most well-known benefit is to act as a stimulant in the body. But do you know how it performs this function? It’s all due to a chemical our body produces called adenosine. When adenosine binds to its receptors in the brain, it signals fatigue, making you tired and sluggish and slows down nerve activity dulling your brain. By binding to adenosine receptors, caffeine prevents this fatigue signal and keeps you more alert and mentally focused. Research confirms that supplementing with caffeine before workouts increases muscle endurance and strength. In addition to its ability to blunt adenosine, caffeine may provide these effects through its ability to boost nitric oxide (NO) levels, which was discovered by Japanese scientists. They reported that subjects taking a dose of caffeine experienced improved blood flow to muscles thanks to increased NO levels. New research also shows that caffeine offers numerous health benefits, such as less cognitive decline with aging and a reduced risk of type 2 diabetes, to name a few.
COCO BEAN EXTRACT
Coco is the plant from which chocolate is made. Bitter chocolate is produced by pressing roasted cocoa kernels (seeds) between hot rollers. Cocoa powder is produced by squeezing the fat (cocoa butter) from bitter chocolate and powdering the remaining material. Sweet chocolate is produced by adding sugar and vanilla to bitter chocolate. White chocolate contains sugar, cocoa butter, and milk solids.
Long regarded as a food treat, cocoa is now used by some people as medicine. Cocoa seed is used for infectious intestinal diseases and diarrhea, asthma,bronchitis, and as an expectorant for lung congestion. The seed coat is used for liver,bladder, and kidney ailments; diabetes; as a tonic; and as a general remedy. Cocoa butter is used for high cholesterol.
You’ve probably heard the buzz about the possible heart health benefits of chocolate, especially dark chocolate. In fact, the candy company Mars, Inc., plans to seek a health claim for chocolate from the Food and Drug Administration (FDA) in the next few years based on research they sponsored regarding the potential role of cocoa flavonoids in cardiovascular health. Flavonoids are chemicals that might lower blood pressure. Dark chocolate contains more flavonoids than milk chocolate or white chocolate. Mars, Inc. is also sponsoring research to see if cocoa flavonoids can help reduce age-related memory decline.
How does it work?
Cocoa contains a variety of chemicals, including antioxidants called flavonoids. It is not clear how these might work in the body, but they appear to cause relaxation of veins. This could lead to lower blood pressure.
GREEN TEA EXTRACT
Green tea is a product made from the Camellia sinensis plant. It can be prepared as a beverage, which can have some health effects. Or an “extract” can be made from the leaves to use as medicine. Green tea is used to improve mental alertness and thinking. It is also used for weight loss and to treat stomach disorders, vomiting, diarrhea, headaches, bone loss (osteoporosis), and solid tumor cancers. Some people use green tea to prevent various cancers, Green tea is also used for Crohn’s disease, Parkinson’s disease, diseases of the heart and blood vessels, diabetes, low blood pressure, chronic fatigue syndrome (CFS), dental cavities (caries), kidney stones, and skin damage.
Epicatechin is present in many plants. High quantities can be found in cocoa, tea and grapes.
Epicatechin is a strong antioxidant, has insulin mimic action and improves heart health. Dr. Norman Hollenberg of Harvard Medical School found that Kuna indians, who live on the San Blas Island Chain in Panama and drink high quantities of cocoa drinks, have a lower risk of stroke, heart failure, cancer and diabetes compared to the Indians living on the mainland. Dr. Norman Hollenberg even suggests to consider epicatechin as a vitamin.
Attenuation of diabetes
Studies show that epicatechin and other flavonoids exert a protective role on osmotic fragility of cells, similar to that of insulin. The mechanism of action of epicatechin is different to that of insulin and remains speculative. In diabetic red blood cells epicatechin causes an increase in acetylcholinesterase activity. This activity is significantly lower in type 2 diabetic patients.
Epicatechin reduces lipid peroxidation and inhibits platelet aggregation. Epicatechin cause blood vessel dilation by regulating nitric oxide, a molecule secreted by the blood vessel endothelium to signal surrounding muscle to relax.
Alpha-GPC is a chemical released when a fatty acid found in soy and other plants breaks down. It is used as medicine.
In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer’s disease. It is available in two forms; one is taken by mouth, and the other is given as a shot. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.
Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, and “mini-stroke” (transient ischemic attack, TIA). Alpha-GPC is also used for improving memory, thinking skills, and learning.
How does it work?
Alpha-GPC seems to increase a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions.
A chemical found in several plants including aconite, Annona squamosa, Nandina domestica (sacred bamboo), and others.
In supplements, higenamine is now showing up in products promoted as a pre-workout supplement for improving athletic performance. There is also interest in using higenamine for weight loss, cough, asthma, heart failure, and erectile dysfunction.
How does it work?
Higenamine works like a stimulant. In some parts of the body it causes tissues to relax. In other parts of the body, such as the heart, it causes tissue to contract. It seems to increase heart contractions and speed up the heart rate.
Halostachine, also known as N-methylphenylethanolamine, is an extract of the plant Halostachys capsica.
Halostachine was first introduced to the supplement market because of their fat burning function. Researchers claim that Halostachine works similarly to ephedrine in burning fat since Halostachine owns the similar structure with ephedrine.
Ephedrine alkaloids are members of a large family of sympathomimetic compounds that include dobutamine and amphetamine. Members of this family increase blood pressure and heart rate by binding to both alpha- and beta-adrenergic receptors present in many parts of the body, including the heart and blood vessels. These compounds are called sympathomimetics because they mimic the effects of epinephrine and norepinephrine, which occur naturally in the human body.
Usually fat loss drugs like ephedrine and clenbuterol are beta adrenergic receptor agonists. This stimulation causes fat to be released to be burned as energy. One paper that examined adrenaline and compounds similar in structure to adrenaline noted that Halostachine is indeed a beta adrenergic receptor agonist with properties similar to adrenaline. Furthermore, Halostachine was found to be about 19% as effective as adrenaline in stimulating cAMP accumulation as a result of beta agonism.
All these evidences prove Halostachine HCl to be a very good botanical adrenergic receptor agonist. Gain more lean mass and burn fat, Halostachine HCl is really a nice gift from Halostachys capsica.
OCTOPAMINE is one of the lesser-known nootropic compounds that is starting to now receive more attention. User reviews say that it gives them more energy, makes it easier to focus, enhances motivation and is effective as a wakefulness promoter. Octopamine is what is known as an endogenous biogenic amine that is closely related to the hormone norepinephrine. From a chemical standpoint, this means that it is an organic compound that contains a basic nitrogen atom with a lone pair (or a valence electron pair without bonding or sharing with other atoms). It is a derivative of ammonia with the hydrogen being at least partially replaced.
This supplement is derived from tyramine, a natural amino acid that is found in foods like tomatoes and liver. The supplement was discovered in 1948 by the Italian scientists Vittorrio Erspamer within the salivary glands of the octopus (hence its unique name). Interestingly enough, this supplement occurs naturally in a number of invertebrates and acts in a number of different functions including as a neurotransmitter, neurohormone, and a neuromodulator. In vertebrates this supplement is thought to replace norepinephrine in neurons involved in the sympathetic nervous system when taking MAOIs.
Octopamine works by stimulating beta3 adrenergic receptors, causing the breakdown of fat cells in the body, among other mechanisms of action. This is effected by mobilization of the release of fat from adipocytes (or fat cells). This has, of course, given rise to the investigation of this supplement as a slimming and potential weight loss agent.
Octopamine also works by acting as a neurohormone, neuromodulator, and even as a neurotransmitter in the human body. It appears to work by affecting and modulating both the noradrenaline (norepinephrine) and the Dopamine systems within the brain. Unfortunately, a number of human studies are lacking, which is partly responsible for the lack of understanding of these methods of action.
There are some noted nootropic benefits of Octopamine, though this supplement is not extensively used as a nootropic. As an agonist of certain adrenergic receptors in the brain, Octopamine has a stimulating effect and can increase energy, alertness, vigilance and awareness. Some users will take it when they really need to focus for long periods of time or increase their drive to attack a project at work or school. It has been compared to Adderall and Ritalin for these purposes, though in the nootropic community drugs like Adrafinil and Modafinil are still preferred.
Probably the most common use of this supplement is as a fat burner and weight loss agent. Since there is evidence to suggest that this supplement aids in the release and breakdown of fats this could be a significant benefit for most people. It has indeed been used in many types of fat-loss products already. Additionally, it is less likely to lose effectiveness over longer periods of time, which is a significant benefit over many other fat burning products that tend to only work well for a few weeks.
Octopamine is also thought to increase the metabolism of the body. This ends up burning more calories and helping with weight loss. It supports insulin secretion and sensitivity which may lead to reductions in the symptoms of diabetes sufferers. There is also some thought that the supplement may lead to a reduced appetite, although this is still being researched.
Octopamine is used to treat low blood pressure and heart disease (in some cases). There is some evidence suggesting it may stimulate the release of chemicals known as catecholamines. These are hormones similar to adrenaline that can help the body adjust to, and deal with, stress.
Athletes who are looking to prevent muscle loss while dieting, like bodybuilders and fitness athletes, might benefit significantly from this supplement. This is due to the thinking that Octopamine may prevent the breakdown of protein for energy. This leads to preserving that hard built muscle mass.
As a beta 3 adrenergic agonist, Octopamine is able to potentially play a role in almost all of the body’s metabolic processes. These receptor are very active and may also lead to fat loss. The most effective role of the supplement here is that it seems to ONLY activate these beta 3 receptors, while leaving all the others alone. This effect alone should help to increase the body’s overall ability to burn fat.
Piperine for mood support:
Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms.
In this study, we investigated the antidepressant effect of piperine in mice exposed to chronic mild stress procedure. Repeated administration of piperine for 14 days at the doses of 2.5, 5 and 10 mg/kg reversed the stress -induced changes in sucrose consumption, plasma corticosterone level and open field activity. Furthermore, the decreased proliferation of hippocampal progenitor cells was ameliorated and the level of brain-derived neurotrophic factor in hippocampus of CMS stressed mice was up-regulated by piperine treatment in the same time course. In summary, up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity might be mechanisms involved in the antidepressant like effect of piperine.
Piperine as antioxidant:
Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats.
The main aim of this study was to investigate the effect of piperine on erythrocyte antioxidant status in high fat diet (HFD) and antithyroid drug induced hyperlipidemic rats. Male Wistar rats were divided into eight groups. The first four groups were fed a control diet and in addition were given respectively 1% carboxymethyl cellulose (CMC); 10 mg/kg body weight carbimazole (CM); 10 mg CM + 40 mg/kg body weight piperine and 10 mg CM + 2 mg/kg body weight atorvastatin. A similar pattern was followed for the next four groups except that they were all fed HFD instead of the control diet. Erythrocyte osmotic fragility, total cholesterol, phospholipids, lipid peroxidation products, enzymic and non-enzymic antioxidant status were studied in all experimental groups. Significantly increased osmotic fragility, total cholesterol/phospholipid ratio, thiobarbituric acid reactive substances and lipid hydroperoxides were observed in the plasma and erythrocytes of HFD fed and CM treated rats compared to the control. Superoxide dismutase, catalase, glutathione peroxidase, vitamin E and reduced glutathione in erythrocytes and vitamin C in the plasma were also significantly lowered in HFD fed, antithyroid drug treated rats compared to control animals. Concurrent piperine supplementation along with HFD and antithyroid drug administration normalized erythrocyte osmotic fragility, reduced lipid peroxidation, and improved the enzymic and non-enzymic antioxidant status compared to those rats that did not receive piperine. Piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in HFD fed antithyroid drug treated rats.
Piperine and blood pressure:
It appears that piperine may lower blood pressure but could also constrict blood vessels. Different animals appear to have a different response to the effects of piperine. The influence of a piperine supplement on blood pressure in humans remains to be evaluated.
Blood pressure lowering and vasomodulator effects of piperine.
J Cardiovasc Pharmacol. 2008. Department of Pharmaceutical Sciences; Federal Urdu University of Arts, Science and Technology, Gulshan Campus Karachi, Pakistan.
This study was aimed to explore underlying mechanism(s) of cardiovascular effects of piperine. Intravenous administration of piperine caused a dose-dependent (1 to 10 mg/kg) decrease in mean arterial pressure in normotensive anesthetized rats; the next higher dose (30 mg/kg) did not cause any further change in mean arterial pressure. The fall in blood pressure was followed by small increase in MAP after each dose. In Langendorrf's rabbit heart preparation, piperine caused partial inhibition and verapamil caused complete inhibition of force and rate of ventricular contractions and coronary flow. In rabbit aortic rings, piperine inhibited high K+ precontractions and partially inhibited phenylephrine (PE), suggesting Ca2+ channel blockade. In rat aorta, piperine demonstrated endothelium-independent vasodilator effect and was more potent against high K+ precontractions than PE. Our data indicate that piperine possesses a blood pressure-lowering effect mediated possibly through calcium channel blockade, while consistent decrease in BP was restricted by associated vasoconstrictor effect. Additionally, species selectivity exists in the calcium channel blockade effect of piperine.
As an appetite and thirst suppressant:
As an appetite and thirst suppressant. Native South Africans, notably the Khoi-San herders, have used this plant for centuries in order to endure extended periods of time without food or water. This quality may render this plant useful as a treatment for obesity, but more controlled research in humans is needed. The active compound responsible for the plant’s appetite suppressant action is a pregnane glycoside (similar in structure to a cardiac glycoside), which has been isolated and patented as P57, although it is possible that more than one compound is responsible for this action. Hoodia gordonii also contains saponins. This compound acts on the central nervous system (CNS), but may also be active peripherally on appetite regulation, via the vagal afferent nerves, as well as on potentially anorectic peripheral hormones such as cholecystokynin (CKK), for example. Limited data involving a clinical trial with 18 obese men report a favorable effects related to appetite suppression and weight loss. In this trial, the plant was well tolerated by the participants and no significant adverse effects were reported.
Yohimbine HCL is a potent vasodilator, which means that it increases blood flow to the extremities, which is what is thought to be responsible for yohimbine's effect on increasing sex drive.
This amino acid forms the dipeptide (a double amino-acid protein) carnosine, which helps muscles contract with more force. Research suggests that taking beta-alanine before training promotes muscle strength and power. It can also enhance muscle endurance. One way to tell if your supp has enough beta-alanine is if your skin, especially around your lips, gets tingly or itchy.
The research for β-alanine clearly shows it is a powerful supplement that when combined with specific other supplements significantly increases strength, lean body mass, power and muscular endurance. Research also shows that supplementing with β-alanine for as short as 4 weeks with as little as 1.6g/day has a dramatic effect on athletic performance in numerous categories. It also shows that supplementing with Beta Alanine for longer duration with higher dosages (12 wks or more @ 3.0+g/day) has an even greater effect on performance
Physical performance. Research suggests that increasing vitamin E intake in the diet is linked with improved physical performance and muscle strength.
How does it work?
Vitamin E is an important vitamin required for the proper function of many organs in the body. It is also an antioxidant. This means it helps to slow down processes that damage cells.
Is a natural phenylalanine-related chemical that occurs in a number of different plants such as barley grass and bitter orange. Also known as N,N-dimethyltyramine, this compound is a N-methyl derivative of the amino acid tyramine. Hordenine is also increasingly being used as a Nootropic that works to improve cognitive function, stimulate higher energy levels and improve your mood. This nootropic is used as an herbal MAO inhibitor to promote focus, concentration and even euphoric feelings.